Mohammad Mirjalili
Islamic Azad University, Iran
Title: Preparation and properties of Polymeric nanofiber containing polyamidoamin as wound dressings
Biography
Biography: Mohammad Mirjalili
Abstract
In recent years, healthcare professionals are confronted with patients who suffer and suffer from healing and covering of wounds and burns. During healing, wound dressing protects from wounds and injuries and contributes to the repair and recovery of skin and skin tissues. Due to biocompatibility, biodegradability and their similarity to macromolecules known to man, some natural polymers, including polysaccharides, proteins and peptides, as well as some synthetic polymers such as polyglycolic acid, polylactic acid, polyacrylic acid, polyvinyl Alcohol and. . . It is widely used in the treatment of wounds and burns. In this study, polyvinyl alcohol (PVA) / carboxymethylcellulose (CMC) / polyamidoamine (PAMAM) / tetracycline (Tet) nanofibers was prepared as an electrospinning wound dressing. First, the antibacterial effect of PAMAM on two E. coli and S.Aureus bacteria was investigated and according to the results of PVA / CMC / 15% PAMAM samples were selected as optimal. Then, the release strength of different levels of tetracycline antibiotics (1, 3, 5 and 7% by weight) was investigated to prevent nanofiber-dressed wound infection. The morphology of composite nanofibers was studied with field emission electron microscopy (FESEM). The chemical structure of the nanofibers was studied by infrared spectroscopy (FTIR) and the results of its release profile from all nanofibres were showed that its highest release occurred within the first 12 hours. Fiber membranes containing 1, 3 and 5% by weight of tetracycline have shown drug release for more than 28 days, and for nanofibers containing 7% tetracycline over 14 days. Regarding the results of the release nanofiber wound dressings of the PVA / CMC / 15% PAMAM/ 5% Tet and the surface morphology of this nanofibre, it can be stated that the amount of by weight of Tet is optimal. FTIR spectroscopy results show the successful placement of tetracycline, polyamidoamine in nanofibres.