Yuqi Yang
Central China Normal University, China
Title: Labeling cells with fluorinated silicon nanoparticles for targeted 19F-MRI and Fluorescence Imaging
Biography
Biography: Yuqi Yang
Abstract
As a noninvasive molecular imaging modality, optical imaging provides high sensitivity and specificity but poor tissue penetration depth. On the contrary, MRI has high spatial resolution in deep tissue, but it suffers the drawbacks of low sensitivity. The combination of MRI and optical imaging, which takes advantages of both modalities, has received widespread attention in biological and medical application. Compared to conventional 1H-MRI, 19F-MRI displays an intense sensitivity (0.83 relative to 1H) and negligible background signal. Herein, we report a one-pot microwave synthesis of a functionalized 19F CA, fluorinated silicon nanoparticles (19F-SiNP), for targeted detection of A549 lung cancer cells. Moreover, based on the quantum effects of the nano-sized nanoparticles, the 19FSiNP can also act as a label free dye for ultracontrast fluorescent imaging. In vitro and in vivo results shows that the peptide-conjugated 19FSiNP can specifically detect A549 cells for dual 19F-MRI and fluorescence imaging. Such functionalized 19FSiNP can also be labeled to other cancer cells by replacing the targeting group, providing a handy and reliable way for targeted dual-model imaging.
