Day 1 :
Chairman, Department of Pharmaceutical Technology Future University, Egypt
Time : 9:00 AM - 9:30 AM
Dr. Hussein Ammar, Holder of the First Class Golden Medal for Sciences and Arts and the recipient of the 2010 Appreciation State Prize in the realm of Advanced Technological Sciences. Professor Ammar is currently the Chairman, Pharmaceutical Technology Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt; formerly, Dean of the Pharmacy Division, National Research Centre, Cairo, Egypt. He has 123 research papers published in international scientific journals. These research papers cover most of the areas related to pharmaceutics, bio pharmaceutics and pharmacokinetics. Design of new drug delivery systems is not beyond the scope of his interest.
Nanotechnology is attracting great attention worldwide in biomedicine. Targeted therapy based on drug nanocarrier systems enhances the treatment of tumors and enables the development of targeted drug delivery systems.In recent years, theranostics are emerging as the next generation of multifunctional nanomedicine to improve the therapeutic outcome of cancer therapy. Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer.The use of directed enzyme prodrug therapy (DEPT) has been investigated as a means to improve the tumor selectivity of therapeutics. Magnetic DEPT involves coupling the bioactive prodrug-activating enzyme to magnetic nanoparticles that are then selectively delivered to the tumor by applying an external magnetic field. Gene therapy is an attractive method for meeting the needs for curing brain disorders, such as Alzheimer’s disease and Parkinson’s disease. On the other hand, due to the fact that hepatocellular carcinoma (HCC) is resistant to standard chemotherapeutic agents, gene therapy appears to be a more effective cure for HCC patients.Ultrasound-mediated drug delivery is a novel technique for enhancing the penetration of drugs into diseased tissue beds noninvasively. This technique is broadly appealing, given the potential of ultrasound to control drug delivery spatially and temporally in a noninvasive manner.
Executive Vice President and Chairman,Pharmaceutical Research Institute, USA
Keynote: Impact of Nanomedicine on the Future of Medicine: The Road Toward Precision Medicine/Case Studies
Time : 9:30 AM - 10 :00 AM
Dr. Mousa finished PhD from Ohio State University, College of Medicine, Columbus, OH and Post-doctoral Fellowship, University of Kentucky, Lexington KY. He also received his MBA from Widener University, Chester, PA. Dr. Mousa is currently an endowed tenure Professor and Executive Vice President and Chairman of the Pharmaceutical Research Institute and Vice Provost for Research at ACPHS. Prior to his academic career, Dr. Mousa was a senior Scientist and fellow at The DuPont Pharmaceutical Company for 17 years where he contributed to the discovery and development of several FDA approved and globally marketed diagnostics and Therapeutics.He holds over 350 US and International Patents discovering novel anti-angiogenesis strategies, antithrombotics, anti-integrins, anti-cancer, and non-invasive diagnostic imaging approaches employing various Nanotechnology platforms. His has published more than 1,000 journal articles, book chapters, published patents, and books as editor and author. He is a member of several NIH study sections, and the editorial board of several high impact Journals. His research has focused on diagnostics and therapeutics of angiogenesis-related disorders, thrombosis, vascular and cardiovascular diseases.
Over the past few years, evidence from the scientific and medical communities has demonstrated that nanobiotechnology and nanomedicine have tremendous potential to profoundly impact numerous aspects of cancer and other disorders in term of early diagnosis and targeted therapy. The utilization of nanotechnology for the development of new nano-carrier systems has the potential to offer improved chemotherapeutic delivery through increased solubility and sustained retention. One of the major advantages of this cutting edge technology is its unique multifunctional characteristics. Targeted delivery of drug incorporated nanoparticles, through conjugation of tumor-specific cell surface markers, such as tumor-specific antibodies or ligands, which can enhance the efficacy of the anticancer drug and reduce the side effects. Additionally, multifunctional characteristics of the nano-carrier system would allow for simultaneous imaging of tumor mass, targeted drug delivery and monitoring (Theranostics). A summary of recent progress in nanotechnology as it relates specifically to nanoparticles and anticancer drug delivery will be reviewed. Nano Nutraceuticals using combination of various natural products provide a great potential in diseases prevention. Additionally, various Nanomedicine approaches for the detection and treatment of various types of organ specific delivery, vascular targeting, and vaccine will be briefly discussed.
QED Radiations, Hong Kong
Keynote: Nanoparticles and DNA damage
Time : 10:00 AM - 10:30 AM
Thomas Prevenslik developed the simple theory of QED based on the Planck law of QM. Differing from the complex QED by Feynman and others, simple QED assumes any heat absorbed in nanoparticles having high surface-to-volume ratios place interior atoms under high EM confinement that by the Planck law of QM precludes the atoms from having the heat capacity to conserve heat by an increase in temperature. In the instant topic of Nanoparticles and DNA damage, the NPs are not physical entities, but rather are nano globules that form from adjuvants upon mixing with water prior to spraying, the adjuvants added to Monsanto’s herbicide glyphosate to enhance penetration through the leaves of weeds. Since crops are contiguous with weeds, the NPs of nano bubbles finally reside in the crop and upon ingestion in the human. Heat produced in metabolism produces low levels of UV radiation that damages the DNA of nearby cells. Monsanto is urged to stop the use of the glyphosate and adjuvants to avoid DNA damage leading to cancer in the present and successive human generations.
Statement of the Problem: Nanoparticles or NPs are known to cause DNA damage  for over at least the past decades, but the causal relation of NPs to human health remains unknown. Chemical reactions of NPs with the DNA cannot be the causal relation as DNA damage occurs  even with inert gold NPs suggesting a physical causal relation such as high temperature. Photodynamic therapy  is thought to kill cancer cells by high temperatures in laser heating of NPs. Although the laser increases the temperature of surrounding tissue, the NP temperature itself does not because the Planck law of QM requires  the NP heat capacity to vanish. QM stands for quantum mechanics. Methodology: Contrarily, photodynamic therapy does not induce necrosis of cancers by increasing the temperature of the quantum sized NPs, and instead NPs produce EM radiation beyond the UV that induces cancer necrosis suggesting the causal relation of NPs to human health is therefore the well-known genotoxicity of DNA to UV radiation. The wavelength of the emitted EM radiation is, = 2nd, where n and d are the refractive index and diameter of the NP. For NPs having n = 1.5, DNA damage for EM radiation beyond the UVC ( < 254 nm ) occurs  for NP diameters d < 85 nm as shown in Figure 1. Discussion: Solar UV is only thought to cause DNA damage to the skin and may lead to cancer, but cannot penetrate the skin to damage internal organs. However, NPs rescind this paradigm. Indeed, NPs by entering the body in the GM food we eat produce  the low levels UV to damage the DNA of tissue in the gut and digestive tract. The DNA damage from GM food that includes NPs in Monsanto’s Roundup herbicide tot enhances crop yields by controlling weeds in modern agriculture are discussed. GM stands for genetically modified. Recommendations To avoid genetic cancers in human DNA evolution, herbicide manufacturers should stop use of NPs in controlling weeds.