Day 1 :
Keynote Forum
Stoyan Sarg Sargoytchev
World Institute for Scientific Exploration, USA
Keynote: Atlas of atomic nuclear structures according to the BSM-super-gravitation unified theory
Time : 09:10-09:50
Biography:
Stoyan Sarg Sargoytchev has completed his Master’s degree in Electrical Engineering from Technical University, Sofia and PhD in Physics from Bulgarian Academy of Sciences. He has worked with Canadian government institutions and universities and retired from York University. Currently, he is with the World Institute for Scientific Exploration. He has published more than 70 scientific papers in reputed journals and he is an author of a theoretical monograph BSM-SG.
Abstract:
The atlas of atomic nuclear structures (ANS) derived by the basic structures of matter-super-gravitation unified theory (BSM-SG), illustrates the super-dense structure of the elementary particles and atomic nuclei. Their real size and configuration appears hidden due to the revealed space micro-curvature around the atomic nuclei. While they exhibit the same interaction energies as the quantum mechanical models, they are not point-like structures. The atlas provides information about the spatial arrangement of the protons and neutrons in the atomic nuclei. The Z-number trend of the nuclear build-up follows a shell structure that complies strictly with the row-column pattern of the periodic table. They possess identifiable features of oxidation numbers and obey the Hund's rules and Pauli Exclusion Principle. The trend of fast increase in the number of neutrons in comparison to the protons in heavier elements and their spatial positions plays a role in redistribution of the repulsive Coulomb forces between protons. The nuclear structures of the stable isotopes exhibit a higher degree of symmetry with a classical explanation of the nuclear spin. This gives a reasoning why some isotopes are stable and others are not. The proposed physical models could be useful for deeper understanding of the nuclear transmutations and they could be applied in chemistry, biomolecules and different fields of nanotechnology.
Keynote Forum
Shaker A Mousa
Albany College of Pharmacy and Health Sciences, USA
Keynote: Impact of nano-biotechnology on the future of medicine (nanomedicine): The road toward precision medicine
Time : 09:50-10:30
Biography:
Shaker A Mousa finished his PhD from Ohio State University, College of Medicine, Columbus, OH and Post-doctoral Fellowship, University of Kentucky, Lexington KY. He also received his MBA from Widener University, Chester, PA. He is currently an endowed tenure Professor and Executive Vice President and Chairman of the Pharmaceutical Research Institute and Vice Provost for Research at ACPHS. Prior to his academic career, he was a senior Scientist and fellow at The DuPont Pharmaceutical Company for 17 years, where he contributed to the discovery and development of several FDA approved and globally marketed diagnostics and therapeutics. He holds over 350 US and International Patents discovering novel anti-angiogenesis strategies, antithrombotics, anti-integrins, anti-cancer, and non-invasive diagnostic imaging approaches employing various nanotechnology platforms. His has published more than 1,000 journal articles, book chapters, published patents, and books as editor and author. He is a member of several NIH study sections, and the Editorial Board Member of several high impact Journals. His research has focused on diagnostics and therapeutics of angiogenesis-related disorders, thrombosis, vascular and cardiovascular diseases.
Abstract:
Over the past few years, evidence from the scientific and medical communities has demonstrated that nanotechnology and nanomedicine have tremendous potential to profoundly impact numerous aspects of cancer and other disorders in term of early diagnosis and targeted therapy. The utilization of nanotechnology for the development of new nano-carrier systems has the potential to offer improved chemotherapeutic delivery through increased solubility and sustained retention. One of the major advantages of this cutting-edge technology is its unique multifunctional characteristics. Targeted delivery of drug incorporated nanoparticles, through conjugation of tumor-specific cell surface markers, such as tumor-specific antibodies or ligands, which can enhance the efficacy of the anticancer drug and reduce the side effects. Additionally, multifunctional characteristics of the nano-carrier system would allow for simultaneous imaging of tumor mass, targeted drug delivery and monitoring (Theranostics). A summary of recent progress in nanotechnology as it relates specifically to nanoparticles and anti-cancer drug delivery will be reviewed. Nano nutraceuticals using combination of various natural products provide a great potential in diseases prevention. Additionally, various nanomedicine approaches for the detection and treatment of various types of organ specific delivery, vascular targeting and vaccine will be briefly discussed.
Keynote Forum
Hussein O Ammar
Future University, Egypt
Keynote: New trends in nanotechnology-based targeted drug delivery systems
Time : 10:30-11:10
Biography:
Holder of the First Class Golden Medal for Sciences and Arts and the recipient of the 2010Appreciation State Prize in the realm of Advanced Technological Sciences.Professor Ammar is currently the Chairman, Pharmaceutical Technology Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt; formerly, Dean of the Pharmacy Division, National Research Centre, Cairo, Egypt. He has more than 110 research papers published in international scientific journals. These research papers cover most of the areas related to pharmaceutics, biopharmaceutics and pharmacokinetics. Design of new drug delivery systems is not beyond the scope of his interest.
Abstract:
In recent years, theranostics are emerging as the next generation of multifunctional nanomedicine to improve the therapeutic outcome of cancer therapy. Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. The use of directed enzyme prodrug therapy (DEPT) has been investigated as a means to improve the tumor selectivity of therapeutics. Magnetic DEPT involves coupling the bioactive prodrug-activating enzyme to magnetic nanoparticles that are then selectively delivered to the tumor by applying an external magnetic field. Gene therapy is an attractive method for meeting the needs for curing brain disorders, such as Alzheimer’s disease and Parkinson’s disease. On the other hand, due to the fact that hepatocellular carcinoma (HCC) is resistant to standard chemotherapeutic agents, gene therapy appears to be a more effective cure for HCC patients. Ultrasound-mediated drug delivery is a novel technique for enhancing the penetration of drugs into diseased tissue beds non-invasively. This technique is broadly appealing, given the potential of ultrasound to control drug delivery spatially and temporally in a non-invasive manner.
Keynote Forum
Amit Banerjee
Shizuoka University, Japan
Keynote: Room-Temperature Terahertz Microbolometer Arrays for Biomedical Imaging Applications
Time : 11:30-12:10
Biography:
Dr. Amit Banerjee has received Ph.D. degree in Semiconductor Technology from Energy Research Unit, Indian Association for the Cultivation of Science (D.S.T., Govt. of India). Currently He is working in the Advanced Device Research Division, Research Institute of Electronics, Shizuoka University, National University Corporation, Japan as a Scientific Researcher. His current research interest is on Terahertz Technology, including THz devices (sensors and sources) fabrication, materials engineering, and optimization for surveillance, inspection, biomedical, imaging and deep space exploration applications. Amit has co-authored several scientific papers, presented in several international conferences among lead speakers, received several awards including Young Physicist Award, Award by the Metrology Society of India (MSI), Indian Institute of Chemical Engineers (IIChE), Award by Dept. of Atomic Energy (D.A.E.), his work was also featured as a Key Scientific Article contributing to excellence in engineering, scientific and industrial research. Amit is member JSAP, IPS, along with other many International Advisory Committees, Technical Program Committees, acted as Panel Editor, Reviewer for reputed journals.
Abstract:
Terahertz waves lie in the region from 300 GHz to 3 THz (wavelength: 100 µm to 1 mm). Electromagnetic wave with frequency range ~ 1 THz, because of its transparency to many non-polarized materials and finger-print spectral bands of organic- and biomacromolecules, is important for non-contact and non-destructive sensing in various applications. Diverse technologies are using these frequency bands for ultrahigh-speed wireless communications, imaging, and materials analysis. There are several exciting applications of THz spectroscopy and imaging e.g. non-contact and remote inspection of concealed weapons, explosives for homeland security, examination of defects and foreign objects in edibles. Another exciting aspect is the development of THz imaging devices, techniques and instruments for biomedical applications for disease diagnostics at a level of cellular processes and tissues, including cancer signature study, diagnosis of tumors, by thermography and imaging. Other various biomedical applications of THz range from studying biomolecules, including analysis of DNA/RNA, amino acids/peptides, proteins, and carbohydrates etc. However, the present ability of THz technology is still inadequate for actual use in large scale. The overall performance in terms of sensitivity and speed of measurements is unsatisfactory and the manufacturing cost of even the basic devices is not commercially viable. Farther research and development of the sources, detectors, optical elements and measuring techniques as well as sensing systems are crucial for extending the utilization of THz waves. Among lot of issues, the current study details THz detectors and detection systems with promising results in terms of performance such as sensitivity and response speed, convenience in handling and prospective low-cost development. Microbolometer is a radiation detector for infrared (IR) and terahertz (THz) waves. The current report is on the detailed investigation of the materials properties, design requirement and device performance aspects, for the fabrication of uncooled antenna-coupled terahertz microbolometer arrays to be used for biomedical imaging applications.