Yao-Chen Chuang has completed his PhD from National Chiao Tung University and his Postdoctoral Studies from National Health Research Institutes.
Gold nanoparticles (AuNPs) have been excellent candidates in cancer radio therapy. As AuNPs are not biodegradable, concerns about long-term toxicity have restricted their translation into the clinic. Herein, a new type of metabolizable flower-like gold nanoparticles (i.e. gold nano-dandelions, GNDs) is successfully synthesized by environment-friendly route in the presence of gelatin and ascorbic acid assistance and was scalable to gram scale-quantity. A key novel feature of the proposed synthesis is the formation of GNDs grow directly by seed-mediated approach without assistance of additional biodegradable materials and the shapes and sizes are fine-tuning by the synthetic parameters, such as ratio of [HAuCl4]/[gelatin] and seed concentration. Our establish GNDs exhibit important applications in simultaneous enhanced computer tomography (CT) imaging and radiotherapy in comparison with conventional spherical ones. Over time, the biodegradable GNDs degrades under physiological environments that leads to disassembly of the GNDs into debris, which is favorable for efficient body clearance.
Delaram Babaei has completed her MSc degree in Medical Nanotechnology from the Islamic Azad University in Iran.
Nanotechnology is one of the novel platforms for diagnosis and treatment of cancer which nowadays is the most cause of death in Iran and other countries. Gold nano-shells are made of a dielectric core which surrounded by a thin gold shell. By the surface Plasmon resonance (SPR) properties, nano-shells adsorb the near-infrared light (NIR) and generate heat by increasing the local temperature of the tumors which finally cause the photo-thermal ablation of cancerous cells. Herein, we synthesis the silica-gold nano-shells which have a silica core as a dielectric core by which surrounded thin Au layer. In the first step, we made the silica nanoparticles by Stober method. In the next step, the silica nanoparticles aminated with (aminopropyl)triethoxysilane (APTES). The gold nanoparticles have been synthesized separately by two different protocols. The gold nanoparticles were seeded to the aminated silica nanoparticles to produce silica-gold nano-shells. The focus of this project is the discussion of various NIR light and their effects on breast cancerous cells. The MCF-7 breast cancer cells were incubated with the various concentrations of nano-shells and after several hours they exposed to NIR light at 810, 980 nm and 4 W/cm2 for 2 minutes with 1.5 mm spot size. The MTT and alamar blue tests clarify that the cells which are under laser radiation were caused ablation of cancerous cells.